Biochemistry and antigenicity of osteoarthritic and rheumatoid cartilage.

  title={Biochemistry and antigenicity of osteoarthritic and rheumatoid cartilage.},
  author={David J. Schurman and M V Palathumpat and Ajith Desilva and Glen Kajiyama and Robert L. Smith},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={4 3},
The purpose of this study was to test whether cartilage serves as the source or repository of antigenic components active in the stimulation of inflammation in rheumatoid arthritis through an analysis of peripheral blood lymphocyte proliferation. Articular cartilage samples were obtained from patients with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis undergoing joint replacement surgery. Each sample was homogenized and characterized biochemically with respect to the content… CONTINUE READING