Biochemistry and Molecular Biology of Antimicrobial Drug Action

  title={Biochemistry and Molecular Biology of Antimicrobial Drug Action},
  author={Trevor J. Franklin and Glenn A. Snow},
  booktitle={Springer Netherlands},
The development of antimicrobial agents, past, present and future.- Vulnerable shields-the cell walls of bacteria and fungi.- Antimicrobial agents and cell membranes.- Inhibitors of nucleic acid biosynthesis.- Inhibitors of protein biosynthesis.- Antimicrobial drugs with other modes of action.- Attack and defense: drug transport across cell walls and membranes.- The genetic basis of resistance to antimicrobial drugs.- Biochemical mechanisms of resistance to antimicrobial drugs. 
The Role of Transport Mechanisms in Mycobacterium Tuberculosis Drug Resistance and Tolerance
The major mechanisms of small molecule penetration into and efflux from Mycobacterium tuberculosis and other mycobacteria are reviewed, and how these mechanisms may contribute to the development of phenotypic drug tolerance and induction of drug resistance are outlined. Expand
Antimicrobial polymers: mechanism of action, factors of activity, and applications
This mini-review briefly highlights and summarizes the results of studies during the past decade and especially in recent years, which concern the mechanism of action of different antimicrobial polymers and non-leaching microbicidal surfaces, and factors influencing their activity and toxicity, as well as major applications of antimicrobialpolymers. Expand
Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus
This work developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles, enabling study of drug resistance and mode of action in Staphylococcus aureus and particularly MRSA. Expand
Development of Metal Complexes as Potential Antimicrobials
The need for novel approaches to combating microbial infections is as great as ever because of the previously disregarded ability of bacteria to genetically mutate to an extent where future generations of bacteria proved immune to the effects of specific antibiotics. Expand
Telavancin Disrupts the Functional Integrity of the Bacterial Membrane through Targeted Interaction with the Cell Wall Precursor Lipid II
Data indicate that telavancin's membrane mechanism requires interaction with lipid II, a high-affinity target that mediates binding to the bacterial membrane, which provides a mechanistic basis for the improved antibacterial properties of telvancin relative to those of vancomycin. Expand
Positively Charged Polymers as Promising Devices against Multidrug Resistant Gram-Negative Bacteria: A Review
An updated overview concerning the main manufactured types of CAPs, active on Gram-negative bacteria, is herein reported, including synthetic procedure and action’s mechanism. Expand
Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers.
The structure-function relationships of antimicrobial polymers and gene vectors are summarized, with which the design of more advanced nonviral gene vectors is anticipated to be further boosted in the future. Expand
Bacteriophage SPZ7 endolysin: The influence of effectors on the lytic activity of the enzyme on the lysis of gram-negative microorganisms
The possibilities of bacteriophage SPZ7 endolysin functioning in the lysis of gram-negative bacteria “from without” were studied. A significant 1.5–3-fold increase in bacteriophage SPZ7 endolysinExpand
Antimicrobial activity and antibiotic sensitivity of three isolates of lactic acid bacteria from fermented fish product
Three isolates of lactic acid bacteria (LAB) from the fermented food product, Budu, were identified as genus lactobacillus (Lactobacillus casei LA17, Lactobacillus plantarum LA22 and L. paracaseiExpand
Tetracycline and Phenicol Resistance Genes and Mechanisms: Importance for Agriculture, the Environment, and Humans.
Information is provided needed to integrate the biology, taxonomy, and ecology of tetracycline- and phenicol-resistant bacteria and their resistance genes so that informative surveillance strategies can be developed and the correct genes selected. Expand