Biochemistry: Biosynthesis of an organofluorine molecule

@article{OHagan2002BiochemistryBO,
  title={Biochemistry: Biosynthesis of an organofluorine molecule},
  author={D. O'Hagan and Christoph Schaffrath and S. Cobb and J. Hamilton and C. Murphy},
  journal={Nature},
  year={2002},
  volume={416},
  pages={279-279}
}
Although fluorine in the form of fluoride minerals is the most abundant halogen in the Earth's crust, only 12 naturally occurring organofluorine compounds have so far been found, and how these are biosynthesized remains a mystery. Here we describe an enzymatic reaction that occurs in the bacterium Streptomyces cattleya and which catalyses the conversion of fluoride ion and S-adenosylmethionine (SAM) to 5′-fluoro-5′-deoxyfluoroadenosine (5′-FDA). To our knowledge, this is the first fluorinase… Expand
Biodegradation and biotransformation of organofluorine compounds
  • C. Murphy
  • Chemistry, Medicine
  • Biotechnology Letters
  • 2009
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