Biochemistry, function, and deficiency of vitamin B12 in Caenorhabditis elegans.

@article{Bito2016BiochemistryFA,
  title={Biochemistry, function, and deficiency of vitamin B12 in Caenorhabditis elegans.},
  author={Tomohiro Bito and Fumio Watanabe},
  journal={Experimental biology and medicine},
  year={2016},
  volume={241 15},
  pages={
          1663-8
        }
}
Caenorhabditis elegans is a nematode that has been widely used as an animal for investigation of diverse biological phenomena. Vitamin B12 is essential for the growth of this worm, which contains two cobalamin-dependent enzymes, methylmalonyl-CoA mutase and methionine synthase. A full complement of gene homologs encoding the enzymes associated with the mammalian intercellular metabolic processes of vitamin B12 is identified in the genome of C elegans However, this worm has no orthologs of the… CONTINUE READING
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