Biochemical study of recombinant PcrA from Staphylococcus aureus for the development of screening assays.

@article{Dubaele2007BiochemicalSO,
  title={Biochemical study of recombinant PcrA from Staphylococcus aureus for the development of screening assays.},
  author={Sandy Dubaele and Christophe Martin and Jacqueline Bohn and Patrick Ch{\`e}ne},
  journal={Journal of biochemistry and molecular biology},
  year={2007},
  volume={40 1},
  pages={
          7-14
        }
}
Helicases are ubiquitous enzymes, which utilize the energy liberated during nucleotide triphosphate hydrolysis to separate double-stranded nucleic acids into single strands. These enzymes are very attractive targets for the development of new antibacterial compounds. The PcrA DNA helicase from Staphylococcus aureus is a good candidate for drug discovery. This enzyme is unique in the genome of S. aureus and essential for this bacterium. Furthermore, it has recently been published that it is… CONTINUE READING

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