Biochemical studies on strain differences of mice in the susceptibility to nitrogen dioxide.

@article{Ichinose1982BiochemicalSO,
  title={Biochemical studies on strain differences of mice in the susceptibility to nitrogen dioxide.},
  author={T. Ichinose and A. Suzuki and H. Tsubone and M. Sagai},
  journal={Life sciences},
  year={1982},
  volume={31 18},
  pages={
          1963-72
        }
}
Strain differences of mice in their susceptibility to nitrogen dioxide (NO2) were examined by measuring the activities of antioxidative protective enzymes, and the amounts of antioxidants and lipid peroxides in lungs. Four strains of mice: ICR, BALB/c, ddy and C57BL/6 were used in this study and their LC50 values after exposure to NO2 for 16 hr were: 38, 49, 51 and 64 ppm, respectively (1). Genetic strain differences were observed in the enzyme activities, the antioxidant contents and lipid… Expand
Biochemical effects of combined gases of nitrogen dioxide and ozone. II. Species differences in lipid peroxides and antioxidative protective enzymes in the lungs.
Abstract Changes in lipid peroxide (thiobarbituric acid reactant) levels, in the content of non-protein sulfhydryls (NPSH) and total proteins, and in the activities of antioxidative protectiveExpand
Species differences in lipid peroxide levels in lung tissue and investigation of their determining factors
TLDR
The results suggest that TBA value as an index of lipid peroxides in the lungs of animals may be regulated mainly by the contents of VE and NPSH, the composition ratio and the reactivity of each polyunsaturated fatty acid in lung phospholipid fraction. Expand
Biochemical effects on combined gases of nitrogen dioxide and ozone. I. Species differences of lipid peroxides and phospholipids in lungs.
TLDR
The results show the existence of species differences in lipid peroxide formation by exposure to the combined gases of NO2 and O3, and they were found to be related to the contents of antioxidants and the compositions of phospholipids and their fatty acids. Expand
Lipid peroxidation and antioxidative protection mechanism in rat lungs upon acute and chronic exposure to nitrogen dioxide.
TLDR
It was suggested that the increments of antioxidative protective enzyme activities in an early phase were complementary effects to protect cells from damage by lipid peroxides which were increased by nitrogen dioxide exposure, and that the complementary effects are lost in later phases of life-span exposure. Expand
Biochemical and morphological changes in lung tissue and isolated lung cells of rats induced by short-term nitrogen dioxide exposure
TLDR
Combined data from biochemical, morphological, and morphometric analyses of lungs and lung cells suggest that lung cell and tissue oxidant sensitivity and defence largely depends on thecell and tissue organisation, i.e., cell numbers and morphology as well as the ratio of surface area to cytoplasmic volume. Expand
Differential susceptibility to oxidant exposure in inbred strains of mice: Nitrogen dioxide versus ozone
The contribution of genetic background to the pathogenesis of airway responses to environmental agents including air pollutants is becoming increasingly clear. Characterization of genetic mechanismsExpand
Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice.
TLDR
The findings suggest that NiSO4-induced acute lung injury is a complex trait controlled by at least 5 genes (all possibly involved in cell proliferation and surfactant function) and future assessment of these susceptibility genes could provide valuable insights into individual susceptibility to the adverse effects of particulate matter. Expand
Comparison of lung antioxidant levels in humans and laboratory animals.
TLDR
A partial correlation was found between ascorbic acid levels and between NPSH and alpha-T levels in the 5 laboratory animal species and in human lung samples obtained from cancer surgery patients. Expand
Genetic variability in the development of pulmonary tolerance to inhaled pollutants in inbred mice.
TLDR
Significant interstrain variation in polymorphonuclear leukocyte and protein responses was observed between the groups with 1x and 5x exposures, which indicates that genetic background has an important role in the development of pulmonary tolerance. Expand
Effects of Depletion of Ascorbic Acid or Nonprotein Sulfhydryls on the Acute Inhalation Toxicity of Nitrogen Dioxide, Ozone, and Phosgene
AbstractThe effect of depleting lung ascorbic acid (AH2) and nonprotein sulfhydryls (NPSH) on the acute inhalation toxicity of nitrogen dioxide (NO2), ozone (O3), and phosgene (COCl2) wasExpand
...
1
2
...

References

SHOWING 1-10 OF 15 REFERENCES
Studies on biochemical effects of nitrogen dioxide. II. Changes of the protective systems in rat lungs and of lipid peroxidation by acute exposure.
TLDR
The results suggest that the ability of the enzyme systems in lungs to protect against NO2 fluctuated in a complex manner and the activities of the protective enzymes varied inversely with lipid peroxidation. Expand
The effect of enzyme-inducing agents on the survival times of rats exposed to lethal levels of nitrogen dioxide.
  • M. Sagai
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1978
TLDR
The mechanism by which 3-MC protects against nitrogen dioxide-induced lethal pulmonary edema is mediated by the induction of enzyme systems, and is suggested to be particularly effective in male rats. Expand
Drug induction of hepatic glutathione S-transferases in male and female rats*.
TLDR
The drug induction of a group of cytosolic drug-metabolizing enzymes as well as the identification of sex differences in these activities are demonstrated. Expand
Ozone interaction with rodent lung. III. Oxidation of reduced glutathione and formation of mixed disulfides between protein and nonprotein sulfhydryls.
TLDR
Nonprotein sulfhydryls (NPSH), a major source of cellular reducing substances, were examined in lung tissue after short-term exposure of rats to O3, suggesting that NPSH or GSH oxidation during in vivo O3 exposure resulted in formation of mixed disulfides with other sulfHydryl (SH) groups of lung tissue. Expand
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.
TLDR
Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content. Expand
Effect of glutathione peroxidase activity on lipid peroxidation in biological membranes.
TLDR
It appears, therefore, that glutathione peroxidase activity must exert its effect on this system by preventing free radical attack on the polyunsaturated membrane lipids in the first place. Expand
Lipoperoxidation of Lung Lipids in Rats Exposed to Nitrogen Dioxide
Absorption spectra characteristic of diene conjugation and typical for peroxidized polyenoic fatty acids can be induced in rat lung lipids after the rats have been exposed to a scant amount ofExpand
Properties and regulation of glutathione peroxidase.
TLDR
It was concluded that nucleotides interact with the enzyme at a site other than the active center and hence that GSH peroxidase is an allosteric enzyme. Expand
Disulfide reduction in rat liver. I. Evidence for the presence of nonspecific nucleotide-dependent disulfide reductase and GSH-disulfide transhydrogenase activities in the high-speed supernatant fraction.
  • F. Tietze
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1970
TLDR
The nucleotide-dependent disulfide-reducing activity of the supernatant fraction was abolished by exposure to 10−4, m arsenite or by heating at 70 ° for 30 min, treatments which were without effect on the NADPH-specific glutathione reductase activity of these same preparations. Expand
Formation of monohydroxy-polyenic fatty acids from lipid peroxides by a glutathione peroxidase.
TLDR
It is suggested that the extremely rapid enzymic reaction of GSH with lipid hydroperoxides breaks the autocatalytic chain reactions of lipid peroxidation and thus protects the vital cellular compounds from the effect of lipidPeroxides. Expand
...
1
2
...