Biochemical studies on peptide alkaloids: Induction of ion selective mitochondrial swelling

@article{Kawai1977BiochemicalSO,
  title={Biochemical studies on peptide alkaloids: Induction of ion selective mitochondrial swelling},
  author={Kiyoshi Kawai and Yoshinori Nozawa and Yōko Ogihara},
  journal={Experientia},
  year={1977},
  volume={33},
  pages={1454-1454}
}
The effect of frangulanine, a cyclopeptide alkaloid isolated fromHovenia dulcis Thunb., on mitochondrial swelling was studied. Frangulanine induced mitochondrial swelling in 0.15 M KCl solution at the concentration of 6.5 μM. The alkaloid showed ion selectivity on the induction of mitochondrial swelling. Upon addition of frangulanine, mitochondria underwent swelling in 0.15 M KCl or RbCl solution but in neither NaCl nor LiCl solution. 
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