Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.

Abstract

Studies on the mode of action of PT523 [N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], a potent nonpolyglutamatable antifolate, were carried out in sensitive and resistant H35 rat hepatoma cell lines in culture, to compare it with other antifolates, including three dihydrofolate reductase (DHFR) inhibitors, i.e., methotrexate (MTX… (More)

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@article{Rhee1994BiochemicalSO, title={Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.}, author={Martin S. Rhee and John Galivan and Joseph Wright and Andr{\'e} Rosowsky}, journal={Molecular pharmacology}, year={1994}, volume={45 4}, pages={783-91} }