Corpus ID: 12946033

Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.

@article{Weber1983BiochemicalSO,
  title={Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.},
  author={George Weber},
  journal={Cancer research},
  year={1983},
  volume={43 8},
  pages={
          3466-92
        }
}
  • G. Weber
  • Published 1 August 1983
  • Philosophy, Medicine
  • Cancer research
Une connaissance de la strategie biochimique des cellules cancereuses et de la «voie royale» pour la conception de la chimiotherapie anticancereuse dirigee par l'enzymogramme. Dans cet article on souligne l'essence et la substance des progres theoriques et experimentaux vers une connaissance de la strategie biochimique et de la logique de l'expression des genes dans les cellules cancereuses et on identifie un programme enzymatique et metabolique commun dans les diverses tumeurs animales et… Expand
Molecular Targets of Anti-Glutamine Therapy with Acivicin in Cancer Cells
Systematic studies in this laboratory showed that there was an increase in the activities of enzymes of glutamine utilization of pyrimidine and purine biosynthesis in rat hepatomas of differentExpand
Targeting a key enzyme in cell growth: a novel therapy for cancer.
  • Jay Kulsh
  • Biology, Medicine
  • Medical hypotheses
  • 1997
TLDR
Since the free-radical-containing active-site of this enzyme can be disabled by a lone electron, low-level direct electric current should have an inhibitory effect on RR and, thus, on uncontrolled cell proliferation. Expand
Biochemical Strategy of Cancer Cells and the Targeting of Chemotherapy with Tiazofurin, Acivicin, and Dipyridamole
TLDR
The testing of the molecular correlation concept proved that the biochemical strategy of the genome in neoplasia can be identified by elucidating the pattern of gene expression as revealed in the activity, amount, and isozymic program of the key enzymes. Expand
Advances in Brief Phenylacetate : A Novel Nontoxic Inducer of Tumor Cell Differentiation 1
Sodium phenylacetate was found to affect the growth and differentia tion of tumor cells in vitro at concentrations that have been achieved in humans with no significant adverse effects. Treatment ofExpand
Rational enzyme-directed prodrug development : exploiting tumour hypoxia to target the bioactivation of cytotoxic prodrugs
TLDR
The evaluation of three potential prodruglenzyme paradigms that may have application in this context are described, including hypoxia-response-elements to specifically regulate heterologous genes in response to low oxygen tension and the application of such an oxygen-regulated gene-directed enzyme/prodrug therapy to solid tumours may provide chemotherapeutic specificity. Expand
Role of differentiation induction in action of purine antimetabolites
TLDR
Tiazofurin was synergistic in cytotoxicity and in causing differentiation with ribavirin, retinoic acid, and difluorodeoxycytidine, and played an important role in the overall impact of antipurine agents. Expand
Tumor resistance to antimetabolites.
TLDR
The inherent or acquired resistance of certain tumors to cytotoxic drug therapy is a major clinical problem and mechanisms of resistance include mutations, amplification of target genes, altered drug transport, differences in nucleoside and nucleobase salvage pathways, DNA damage-response pathways and cell cycle control pathways. Expand
Regulation of de novo and salvage pathways in chemotherapy.
TLDR
The down-regulation of the ras oncogene by tiazofurin through the decrease of GTP concentration has now been shown in K562, HL-60 and hepatoma cells and in patients with chronic granulocytic leukemia in blast crisis. Expand
Multifunctional modulators of drug resistance.
TLDR
A variety of specific biochemical mechanisms have been identified that allow tumors to escape the cytotoxic effect of chemotherapy, such as the resistance to methotrexate associated with a mutational change in the target enzyme dihydrofolate reductase. Expand
Differential effects of gemcitabine on nucleotide pools of 19 solid tumor cell lines
2,2-Difluorodeoxycytidine (dFdC, Gemcitabine, Gemzar) is a deoxycytidine analogue, which is very active against murine experimental tumor models, human tumor xenografts and in clinical Phase IIExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 150 REFERENCES
Enzyme pattern-directed chemotherapy: synergistic interaction of 3-deazauridine with D-galactosamine.
TLDR
The D-galactosamine-induced depletion of uridine 5'-triphosphate was employed to enhance the growth inhibition caused by 3-deazauridine, and the drug effect was most pronounced in the slower growing, well differentiated hepatoma lines where the activities of certain hepatic metabolic pathways and enzymes were still operative. Expand
Biochemical programs and enzyme-pattern-targeted chemotherapy in cancer cells.
TLDR
It was demonstrated that this drug exerted a clearcut, phase-specific toxicity and was particularly toxic to early G1 and early S phase cells, but had little or no effect on tumor cells in other phases of the cell cycle. Expand
Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193).
TLDR
The drug was producing a state of guanine deprivation was provided by high performance liquid chromatography analysis of acid-soluble extracts: a time-dependent fall in the concentrations of GMP and GTP ensued upon exposure to the drug; on the other hand, IMP concentrations increased by ∼15-fold. Expand
Oxidative metabolism of neoplastic tissues.
  • S. Weinhouse
  • Biology, Medicine
  • Advances in cancer research
  • 1955
TLDR
The chapter highlights the concept of tumor metabolism, which maintains a fundamental thesis that the neoplastic process is somehow associated with disturbances or peculiarities of oxidative metabolism, and reviews the evidence for this concept against the present knowledge of intermediary cell metabolism. Expand
Biochemical commitment to replication in cancer cells.
TLDR
The results are in line with earlier ones in this Laboratory on solid tumors indicating an integrated imbalance of the key enzymes of pyrimidine, purine and carbohydrate metabolism that should confer selective advantages to cancer cells. Expand
Behavior of liver enzymes in hepatocarcinogenesis.
  • G. Weber
  • Biology, Medicine
  • Advances in cancer research
  • 1961
TLDR
This chapter discusses the biological aspects of liver carcinogenesis, and the main question that may be raised is what type of information may be gained by studying enzymatic activities and what the special considerations and conditions are that may have to be taken into account in the evaluation and interpretation of enzyme data. Expand
Action of lycurim and pyrazofurin on hepatoma 3924A cells in culture.
TLDR
Testing for a possible synergism in the antitumor action of the antimetabolite pyrazofurin and the alkylating agent lycurim found that LY killed hepatoma cells in both the exponential and plateau phases. Expand
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
TLDR
Results are consistent with an interpretation that acivicin acts either as a tight-binding inhibitor or as an inactivator through alkylation of the enzymes of glutamine utilization, and the synergistic biological results of combination chemotherapy with ac civicin and actinomycin can be accounted for. Expand
Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism.
TLDR
The present work demonstrates the applicability of the molecular correlation concept and much of the altered biochemical pattern discovered in the rat hepatoma spectrum to other tumors in rat, to lymphomas in mice and to primary kidney tumor in humans. Expand
IMP dehydrogenase, an enzyme linked with proliferation and malignancy
TLDR
Investigation on purine metabolism showed that in the hepatomas there was an increased capacity in the de novo pathway of biosynthesis of inosine 5′-monophosphate (IMP), as reflected in the increased activity of glutamine PRPP amidotransferase and a decrease in IMP catabolism. Expand
...
1
2
3
4
5
...