Biochemical sequences in the transformation of normal fibroblasts in adolescent rats.

@article{Reddi1972BiochemicalSI,
  title={Biochemical sequences in the transformation of normal fibroblasts in adolescent rats.},
  author={A. Hari Reddi and Charles B. Huggins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1972},
  volume={69 6},
  pages={1601-5}
}
Coarse powders of acid-insoluble matrix of diaphysis and calvarial parietal bone rapidly and consistently transformed fibroblasts into masses of cartilage and bone containing hemopoietic marrow. The transformant was encapsulated by fibroblasts within 24 hr to form a plaque. Transformation was restricted to the central thicknesses of the plaque. Under the stated conditions the alteration of the phenotype, fibroblast to chondroblast, was an unstable transformation, whereas the phenotype change… CONTINUE READING
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