Biochemical screening for Down syndrome.

  title={Biochemical screening for Down syndrome.},
  author={H Cuckle},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  volume={92 1},
  • H Cuckle
  • Published 2000 in
    European journal of obstetrics, gynecology, and…
Maternal serum screening for Down syndrome is an established practise in many countries. In the second trimester human chorionic gonadotrophin (hCG) or free beta-hCG is the marker of first choice, with alpha-fetoprotein (AFP) as the second marker and unconjugated oestriol (uE(3)) the third. Statistical models with parameters derived by meta-analysis predict that a three marker combination will yield a 67% detection rate for a 5% false-positive rate. The model prediction have been confirmed in… CONTINUE READING