Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.

@article{Shields2012BiochemicalRO,
  title={Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.},
  author={Mario A Shields and Surabhi Dangi-Garimella and Amanda J. Redig and Hidayatullah G. Munshi},
  journal={The Biochemical journal},
  year={2012},
  volume={441 2},
  pages={541-52}
}
PDAC (pancreatic ductal adenocarcinoma) is among the most deadly of human malignances. A hallmark of the disease is a pronounced collagen-rich fibrotic extracellular matrix known as the desmoplastic reaction. Intriguingly, it is precisely these areas of fibrosis in which human PDAC tumours demonstrate increased expression of a key collagenase, MT1-MMP [membrane-type 1 MMP (matrix metalloproteinase); also known as MMP-14]. Furthermore, a cytokine known to mediate fibrosis in vivo, TGF-β1… CONTINUE READING

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