Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.

@article{Firestine1998BiochemicalRO,
  title={Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.},
  author={Steven M. Firestine and Shawn Misialek and Dena L. Toffaletti and Thomas J. Klem and John R Perfect and Vincent Jo Davisson},
  journal={Archives of biochemistry and biophysics},
  year={1998},
  volume={351 1},
  pages={123-34}
}
Comparative studies of 5-aminoimidazole ribonucleotide (AIR) carboxylases from Escherichia coli and Gallus gallus have identified this central step in de novo purine biosynthesis as a case for unusual divergence in primary metabolism. Recent discoveries establish the fungal AIR carboxylase, encoded by the ADE2 gene, as essential for virulence in certain pathogenic organisms. This investigation is a biochemical analysis that links the fungal ADE2 protein to the function of the E. coli AIR… CONTINUE READING

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