Biochemical responses of rat and mouse lung to inhaled nickel compounds.

  title={Biochemical responses of rat and mouse lung to inhaled nickel compounds.},
  author={Janet M. Benson and D G Burt and Yung Sung Cheng and F F Hahan and Patrick J. Haley and Rogene F. Henderson and Charles H. Hobbs and John A Pickrell and J K Dunnick},
  volume={57 3},
Nickel subsulfide (Ni3S2), nickel sulfate (NiSO4), and nickel oxide (NiO) are encountered occupationally in the nickel refining and electroplating industries, with inhalation being a common route of exposure. The purposes of this study were to evaluate the biochemical responses of lungs of rats and mice exposed for 13 weeks to occupationally relevant aerosol concentrations of Ni3S2, NiSO4, and NiO, to correlate biochemical responses with histopathologic changes, and to rank the compounds by… CONTINUE READING


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