Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain

@article{Ashok2014BiochemicalRA,
  title={Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain},
  author={Iyaswamy Ashok and Rathinasamy Sheeladevi},
  journal={Redox Biology},
  year={2014},
  volume={2},
  pages={820 - 831}
}
  • Iyaswamy Ashok, Rathinasamy Sheeladevi
  • Published 2014
  • Chemistry, Medicine
  • Redox Biology
  • Aspartame, an artificial sweetener, is very widely used in many foods and beverages. But there are controversies about its metabolite which is marked for its toxicity. Hence it is believed to be unsafe for human use. Previous studies have reported on methanol exposure with involvements of free radicals on excitotoxicity of neuronal apoptosis. Hence, this present study is proposed to investigate whether or not chronic aspartame (FDA approved Daily Acceptable Intake (ADI),40 mg/kg bwt… CONTINUE READING

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    Effect of long term intake of aspartame on antioxidant defense status in liver.