Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation

@inproceedings{BeldaPalazn2014BiochemicalQO,
  title={Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation},
  author={Borja Belda-Palaz{\'o}n and Mar{\'i}a Angeles Nohales and Jose Luis Rambla and Jos{\'e} Luis Ace{\~n}a and Oscar Delgado and Santos Fustero and M. C. Mart{\'i}nez and Antonio Granell and Juan Manuel Carbonell and Alejandro Ferrando},
  booktitle={Front. Plant Sci.},
  year={2014}
}
The eukaryotic translation elongation factor eIF5A is the only protein known to contain the unusual amino acid hypusine which is essential for its biological activity. This post-translational modification is achieved by the sequential action of the enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). The crucial molecular function of eIF5A during translation has been recently elucidated in yeast and it is expected to be fully conserved in every eukaryotic cell, however the… CONTINUE READING