Biochemical prototype for familial thrombosis. A study combining a functional protein C mutation and factor V Leiden.

Abstract

Resistance to activated protein C (APC) is associated with a single amino acid substitution in factor V (Arg506-->Gln, factor V Leiden) that results in delayed inactivation of the molecule by APC. The mutation is present in 20% of patients with a first episode of deep venous thrombosis. Arterial and venous thromboses are also associated with the type II… (More)

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Cite this paper

@article{Kalafatis1995BiochemicalPF, title={Biochemical prototype for familial thrombosis. A study combining a functional protein C mutation and factor V Leiden.}, author={Michael Kalafatis and D. Lu and Rogier M. Bertina and George L. Long and Kelly Mann}, journal={Arteriosclerosis, thrombosis, and vascular biology}, year={1995}, volume={15 12}, pages={2181-7} }