Corpus ID: 32643196

Biochemical properties of staphylococci sensitive and resistant to sulphonamides.

@article{White1965BiochemicalPO,
  title={Biochemical properties of staphylococci sensitive and resistant to sulphonamides.},
  author={P. White and D. D. Woods},
  journal={Journal of general microbiology},
  year={1965},
  volume={40 2},
  pages={
          255-71
        }
}
Four staphylococcal substrains resistant to sulphonamides were developed from sensitive parent strains by subcultivation in increasing concentrations of sulphathiazole. As compared with the parent strains, the growth of the resistant strains was 20-200-fold less sensitive to sulphathiazole in a semi-defined medium based on acid hydrolyzed casein than were the parent strains. Inhibition of growth by sulphathiazole was overcome competitively by p-aminobenzoic acid. The inhibition indices of the… Expand
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The synthesis of p-aminobenzoic acid and folic acid was investigated in three strains of Staphylococcus sensitive to sulphonamide drugs, and in four substrains resistant to sulphanamides, and the synthesis of folk acid was not increased when resistance was acquired. Expand
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