Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication

@article{Kitami2002BiochemicalNC,
  title={Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication},
  author={Toshiaki Kitami and Joseph H. Nadeau},
  journal={Nature Genetics},
  year={2002},
  volume={32},
  pages={681-681}
}
To the authors’ dismay, a software bug adversely affected some but not all of the main conclusions of this article. They reported that redundant biochemical networks provide greater genetic buffering than do gene families, on the basis of the rate of gene evolution for genes in the glycolysis/gluconeogenesis and the folate/homocysteine pathways. A bug in software that converted ClustalW alignments into Mega2.1 format considerably affected the data set for these two pathways, which contributed… CONTINUE READING

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