Biochemical network models simplified by balanced truncation.

  title={Biochemical network models simplified by balanced truncation.},
  author={Wolfram Liebermeister and Ulrike Baur and Edda Klipp},
  journal={The FEBS journal},
  volume={272 16},
Modelling of biochemical systems usually focuses on certain pathways, while the concentrations of so-called external metabolites are considered fixed. This approximation ignores feedback loops mediated by the environment, that is, via external metabolites and reactions. To achieve a more realistic, dynamic description that is still numerically efficient, we propose a new methodology: the basic idea is to describe the environment by a linear effective model of adjustable dimensionality. In… CONTINUE READING
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