Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5‐fluorouracil by 5‐bromovinyluracil: Assessment with metabolic 19F MR imaging

  title={Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5‐fluorouracil by 5‐bromovinyluracil: Assessment with metabolic 19F MR imaging},
  author={Gunnar Brix and Matthias E. Bellemann and Uwe Haberkorn},
  journal={Magnetic Resonance in Medicine},
Using chemical shift–selective 19F magnetic resonance (MR) imaging, we investigated the biomodulating action of 5‐bromovinyluracil (BVU) on the degradation of the anticancer drug 5‐fluorouracil (5‐FU) to its major catabolite α‐fluoro‐β‐alanine (FBAL) and the tissue uptake of 5‐FU in ACI rats with transplanted Morris hepatoma. Rats in the control group (n = 7) received 200 mg/kg body weight of 5‐FU intravenously, whereas the rats in the BVU group (n = 7) additionally received 30 mg/kg body… 
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5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model.
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