Biochemical mechanisms of drug action: what does it take for success?

@article{Swinney2004BiochemicalMO,
  title={Biochemical mechanisms of drug action: what does it take for success?},
  author={D. C. Swinney},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={801-808}
}
  • D. C. Swinney
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • Drug discovery is extremely difficult. There are many unanticipated scientific, medical and business challenges to every drug discovery programme. It is important to increase our understanding of the fundamental properties of effective drugs so that we can anticipate potential problems in developing new agents. This article addresses potential drug discovery and development risks associated with the biochemical mechanism of drug action, and proposes simple rules to minimize these risks. 
    275 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Paper Mentions

    Mechanism of Action Assays for Enzymes
    • 50
    Opportunities to minimise risk in drug discovery and development
    • D. C. Swinney
    • Biology, Medicine
    • Expert opinion on drug discovery
    • 2006
    • 3
    Rethinking mechanisms of drug discovery
    • 2
    • PDF
    Mechanistic enzymology in drug discovery: a fresh perspective
    • 19
    Challenges and Hurdles to Business as Usual in Drug Development for Treatment of Rare Diseases
    • 6
    Drugs, their targets and the nature and number of drug targets
    • 439
    • PDF
    Recent advances in phenotypic drug discovery
    • PDF

    References

    SHOWING 1-10 OF 69 REFERENCES
    The druggable genome
    • 2,624
    • PDF
    Granisetron: relating pharmacology to clinical efficacy
    • P. Blower
    • Medicine
    • Supportive Care in Cancer
    • 2002
    • 39
    Enzyme Inhibition in Open Systems
    • 46
    • PDF
    The Molecular Pharmacology of SERMs
    • D. McDonnell
    • Biology, Medicine
    • Trends in Endocrinology & Metabolism
    • 1999
    • 301
    Progesterone receptor and the mechanism of action of progesterone antagonists
    • 77