Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks.

@article{Povirk2006BiochemicalMO,
  title={Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks.},
  author={Lawrence F. Povirk},
  journal={DNA repair},
  year={2006},
  volume={5 9-10},
  pages={1199-212}
}
Exposure of mammalian cells to agents that induce DNA double-strand breaks typically results in both reciprocal and nonreciprocal chromosome translocations. Over the past decade, breakpoint junctions of a significant number of translocations and other genomic rearrangements, both in clinical tumors and in experimental models, have been analyzed at the DNA sequence level. Based on these data, reasonable inferences regarding the biochemical mechanisms involved in translocations can be drawn. In a… CONTINUE READING

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