Biochemical mechanism of DSB end resection and its regulation.

  title={Biochemical mechanism of DSB end resection and its regulation.},
  author={James M Daley and Hengyao Niu and Adam S Miller and Patrick Sung},
  journal={DNA repair},
DNA double-strand breaks (DSBs) in cells can undergo nucleolytic degradation to generate long 3' single-stranded DNA tails. This process is termed DNA end resection, and its occurrence effectively commits to break repair via homologous recombination, which entails the acquisition of genetic information from an intact, homologous donor DNA sequence. Recent advances, prompted by the identification of the nucleases that catalyze resection, have revealed intricate layers of functional redundancy… CONTINUE READING
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