Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study.

@article{Vulpen2015BiochemicalMO,
  title={Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study.},
  author={Lize F D van Vulpen and Monique E.R. van Meegeren and G. P. M. Roosendaal and Nathalie W D Jansen and Jacob M van Laar and Roger E. G. Schutgens and Simon C. Mastbergen and Floris P. Lafeber},
  journal={Osteoarthritis and cartilage},
  year={2015},
  volume={23 1},
  pages={63-9}
}
OBJECTIVE Evaluation whether biomarkers of joint damage are sensitive to change shortly after a joint bleed in hemophilia patients and in a canine model of blood-induced joint damage. METHODS Blood and urine samples were collected from 10 hemophilia patients after they reported a joint bleed: within 2 days, after 3-5 days, and 12-14 days. Additionally, 90… CONTINUE READING