Biochemical implications of sequence comparisons of the cystic fibrosis transmembrane conductance regulator.

@article{Tan2002BiochemicalIO,
  title={Biochemical implications of sequence comparisons of the cystic fibrosis transmembrane conductance regulator.},
  author={Agnes Lay-Choo Tan and Serene A. K. Ong and Byrappa Venkatesh},
  journal={Archives of biochemistry and biophysics},
  year={2002},
  volume={401 2},
  pages={215-22}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that is both of medical significance in humans and of interest with regard to osmoregulation in aquatic organisms. CFTR is composed of five domains: two membrane-spanning domains, two nucleotide-binding domains, and a regulatory domain. Notwithstanding the plethora of information concerning the structure and function of CFTR, the biochemistry of many facets of CFTR are not completely understood. In this regard… CONTINUE READING