Biochemical heterogenity of the left ventricular myocardium: transmural and base-apex gradients on H.E.P. contents of the well oxygenated perfused dog heart.


An investigation into the contents (mumol/g w.w.) of the creatine phosphate (CP) and adenosine triphosphate (ATP) of various myocardial regions was performed on the empty beating isolated blood perfused dog heart. Across the myocardial wall, CP concentration was higher in the outer portion (9.03 +/- 0.18) than in the inner portion (8.59 +/- 0.20) (P less… (More)