Biochemical factors in alcoholic liver disease.

  title={Biochemical factors in alcoholic liver disease.},
  author={Charles S. Lieber},
  journal={Seminars in liver disease},
  volume={13 2},
Three decades of research in ethanol metabolism have established that alcohol is hepatotoxic not only because of secondary malnutrition, but also through metabolic disturbances associated with the oxidation of ethanol. Some of these alterations are due to redox changes produced by the NADH generated via the liver ADH pathway, which in turn affects the metabolism of lipids, carbohydrates, proteins, and purines. Exaggeration of the redox change by the relative hypoxia, which prevails… CONTINUE READING


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