Biochemical evidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip.

@article{Mansell1997BiochemicalEF,
  title={Biochemical evidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip.},
  author={Jason Peter Mansell and John Tarlton and Allen J. Bailey},
  journal={British journal of rheumatology},
  year={1997},
  volume={36 1},
  pages={16-9}
}
Osteoarthritis (OA) of the hip is invariably viewed as a disease primarily affecting the articular cartilage. Data presented in this report, however, demonstrate changes in the metabolic activity of the underlying trabecular bone tissue, the processes of which may represent a significant factor in the pathogenesis of hip OA. Trabecular bone tissue from OA subjects expressed significantly more matrix metalloproteinase (MMP)-2 (gelatinase A, 72 kDa type IV collagenase) when compared to age… CONTINUE READING