Biochemical effects of carbamazepine: Relationship to its mechanisms of action in affective illness

  title={Biochemical effects of carbamazepine: Relationship to its mechanisms of action in affective illness},
  author={Robert M. Post and Thomas W Uhde and David R Rubinow and James C. Ballenger and Philip W. Gold},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • R. PostT. Uhde P. Gold
  • Published 31 December 1983
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Neuroendocrine Effects of Carbamazepine in Patients with Affective Illness

Caramazepine, a drug that is clinically effective in paroxysmal pain syndromes and in epilepsy, also appears to be effective in the treatment of manic‐depressive illness and the hormone responses to sequential stimuli were studied.

Treatment of Mood Disorders with Antiepileptic Medications: Clinical and Theoretical Implications

Clinical studies and reviews of at least one anticonvulsant, carbamazepine, suggest that many patients may experience positive effects on mood and behavior while being treated for their seizure disorders with this agent, although this remains controversial.

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  • 1988
Carbamazepine is a tricyclic compound structurally related to imipramine that has been used since the 1960's for the treatment of trigeminal neuralgias and then approved as an anticonvulsant in the

Effect of carbamazepine on thyroid hormone measurement in vitro.

  • D. BlankR. Joffe
  • Medicine, Psychology
    Clinica chimica acta; international journal of clinical chemistry
  • 1984

Perspectives on the use of anticonvulsants in the treatment of bipolar disorder.

The preliminary data evaluating the efficacy of newer anticonvulsants in bipolar patients is still limited, but some of the available findings are promising, and these new agents may represent appropriate third choices for refractory bipolar individuals.

Effect of Carbamazepine on Dopamine Release and Reuptake in Rat Striatal Slices

Caramazepine has been shown to enhance dopaminergic agonist behavioral effects, but not to displace [3H]spiroperidol binding, and acts presynaptically on striatal neurons, mainly through enhancement of dopamine release.



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Biochemical and physiological mechanisms of action of carbamazepine in affective illness

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Effect of carbamazepine in polyuria associated with lithium therapy.

  • K. Ghose
  • Medicine, Psychology
    Pharmakopsychiatrie, Neuro-Psychopharmakologie
  • 1978
It appears that lithium exacerbates carbamazepine induced CNS side-effects or vice versa, the mechanism of which is not very clear, and simultaneous administration of these two drugs should preferably be avoided.

A Lithium and Carbamazepine Combination in the Treatment of Bipolar Disorder–A Preliminary Report

Clinical results suggest that a lithium and carbamazepine combination may be more efficacious in the treatment of acute manic episode and the prevention of affective recurrences than each drug alone.


  • V. Neppe
  • Psychology, Medicine
    The Lancet
  • 1982

Lack of effect of carbamazepine on gamma‐aminobutyric acid in cerebrospinal fluid

Preliminary data do not support a major effect of carbamazepine on brain GABA as reflected in CSF as a mechanism for its anticonvulsant or psychotropic effects.


Carbamazepine and its -10,11-epoxide metabolite in plasma and CSF. Relationship to antidepressant response.

The possibility that the -10,11-epoxide metabolite of carbamazepine may be related to the degree of clinical efficacy in affectively ill patients and may thus possess active psychotropic properties in man in addition to its reported anticonvulsant effects in animals is suggested.

The March of Symptoms in a Psychotic Decompensation Case Report and Theoretical Implications

The onset and evolution of symptoms were studied in a female patient with a history of recurrent depressive psychoses, characterized by an orderly and progressive sequence including similar psychological or somatic precipitants, mounting anxiety, nystagmoid eye movements associated with panic, unfolding delusions, and olfactory hallucinations.