Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver.

@article{Just1989BiochemicalEA,
  title={Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver.},
  author={Wilhelm W. Just and Karin Gorgas and F. Ulrich Hartl and Paul H. Heinemann and Martin Salzer and Heidelberg D Schimassek},
  journal={Hepatology},
  year={1989},
  volume={9 4},
  pages={570-81}
}
Rats were treated for 5 to 14 days with perfluoroacetate, perfluorobutyrate and perfluorooctanoate. Alterations in hepatic morphology with special reference to the peroxisomal compartment were investigated by light and electron microscopy following cytochemical staining of catalase activity with the alkaline 3,3'-diaminobenzidine medium. All three compounds induced hepatomegaly and peroxisome proliferation. Perfluorobutyrate and perfluorooctanoate were found to be more active than… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water.

Toxicological sciences : an official journal of the Society of Toxicology • 2008
View 4 Excerpts
Highly Influenced

Derivation of a drinking water equivalent level (DWEL) related to the maximum contaminant level goal for perfluorooctanoic acid (PFOA), a persistent water soluble compound.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2009
View 2 Excerpts

Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys.

Toxicological sciences : an official journal of the Society of Toxicology • 2002

Changes in tropospheric composition and air quality.

Journal of photochemistry and photobiology. B, Biology • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…