Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma.

@article{Pulford1999BiochemicalDO,
  title={Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma.},
  author={Karen Pulford and Brunangelo Falini and Jacqueline Cordell and Andreas Rosenwald and German Ott and Hans-Konrad Mueller-Hermelink and Kenneth A Maclennan and Laurence Lamant and Antonino Carbone and El{\'i}as Campo and David Mason},
  journal={The American journal of pathology},
  year={1999},
  volume={154 6},
  pages={1657-63}
}
The (2;5) translocation, found in many T-cell and null cell anaplastic large cell lymphomas (ALCLs), creates a hybrid gene encoding the 80-kd NPM-ALK protein. Typically neoplastic cells show labeling of both nucleus and cytoplasm for anaplastic lymphoma kinase (ALK) and for the N-terminus of nucleophosmin (NPM). However, 10-20% of cases exhibit cytoplasmic labeling only for ALK, indicating the probable presence of variants of the classical (2;5) translocation that do not involve the NPM gene… CONTINUE READING