Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

@article{Poddar2019BiochemicalDA,
  title={Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements},
  author={Jit Poddar and Munmun Pradhan and Gargi Ganguly and Sasanka Chakrabarti},
  journal={Journal of Chemical Neuroanatomy},
  year={2019},
  volume={95},
  pages={70-80}
}
The aging of brain in the absence of neurodegenerative diseases, usually called non-pathological brain aging or normal cognitive aging, is characterized by an impairment of memory and cognitive functions. The underlying cellular and molecular changes in the aging brain that include oxidative damage, mitochondrial impairment, changes in glucose-energy metabolism and neuroinflammation have been reported widely from animal experiments and human studies. The cognitive deficit of non-pathological… Expand
Neural functions of the aging brain: Daily living, developmental and geriatric disabilities
TLDR
There is a void in geriatric and developmental neuroscience research in India since huge data mining and translation, concerted efforts on clinical neuroscience research, and consistent efforts on pure basic research resulting in 'first in the field' novelty are largely missing. Expand
Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions
TLDR
This review aims to describe the nutritional factors that have been researched so far which may lead to the development of frailty, and especially cognitive decline. Expand
The Interest of Adding Micronutrients to Docosahexaenoic Acid Supplementation to Prevent Age-Related Cognitive Decline
TLDR
The effects of the Mediterranean diet which constitutes the most complete association of nutrients and DHA from fish, vitamins and polyphenols from fruits and vegetables represents a global vision of nutrition are described and the interest of combining DHA and micronutrients contained in this diet as well as pre- and probiotics are focused on. Expand
Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease
TLDR
The routes of interaction between epigenetic mechanisms and the microbiota–gut–brain axis have been elucidated, thus establishing a modulatory role of diet-induced epigenetic changes of gut microbiota in shaping the brain. Expand
Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders
TLDR
Preclinical studies supporting the possibility that ASK1 regulation is a promising target for the prevention/treatment of cognitive disorders are reviewed and future studies are necessary to investigate the role of ASK 1 in the pathogenic mechanisms underlying cognitive dysfunctions, for the translation of preclinical information into clinical application. Expand
Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements
TLDR
Whereas multiple studies indicate that omega fatty acids can protect against neurodegeneration in older adults, more work is needed in the years preceding the diagnosis of such medical conditions, Bearing in mind the scale of ageing populations and rising healthcare costs linked to poor brain health, omega supplementation could be a useful strategy for helping to augment dietary intakes and support brain health across the lifespan. Expand
Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease.
TLDR
The present work opines that the mechanism by which the insulin resistance mediates dysregulation of bioenergetics and progresses to neurodegenerative state holds the tangible potential to succeed in the development of novel dementia therapies. Expand
Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model.
TLDR
It is revealed that chronic D-Gal exposure in mice led to cognitive impairment in MWM, along with cholinergic malfunction, extensive oxidative stress and neuroinflammation, as well as hyperphosphorylation of tau protein in hippocampus, which could be ameliorated by 4-week repeated piperine administration. Expand
Pharmacological implications of ipriflavone against environmental metal–induced neurodegeneration and dementia in rats
TLDR
Ipriflavone significantly (P < 0.05) ameliorated the neurobehavioral abnormalities and the cognitive dysfunction biomarkers via antioxidant/anti-inflammatory mechanism and could provide a new strategy in AD treatment. Expand
The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease
TLDR
The composition of neuroVascular unit and the role of neurovascular unit damage in the occurrence and development of AD were reviewed, and it was found that neurofibrillary tangles are the basic pathological changes of AD. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 224 REFERENCES
Nutrition, Brain Aging, and Neurodegeneration
TLDR
It is important to determine what methods can be used today to increase healthy aging, forestall the onset of age-related neurodegenerative diseases, and create conditions favorable to obtaining a “longevity dividend” in both financial and human terms. Expand
The beneficial effects of fruit polyphenols on brain aging
TLDR
Research from the laboratory has shown that nutritional antioxidants, such as the polyphenols found in blueberries, can reverse age-related declines in neuronal signal transduction as well as cognitive and motor deficits and that short-term blueberry supplementation increases hippocampal plasticity. Expand
Brain fuel metabolism, aging, and Alzheimer's disease.
TLDR
It is suggested that brain hypometabolism may precede and therefore contribute to the neuropathologic cascade leading to cognitive decline in AD, and strategies to reduce the risk of AD should aim to improve insulin sensitivity by improving systemic glucose utilization, or bypass deteriorating brain glucose metabolism using approaches that safely induce mild, sustainable ketonemia. Expand
Energy metabolism and inflammation in brain aging and Alzheimer's disease.
TLDR
This review focuses on the alterations in energy metabolism and inflammatory responses and their connection via redox regulation in normal brain aging and Alzheimer's disease. Expand
Brain metabolism in health, aging, and neurodegeneration
TLDR
It is suggested that lifestyles that include intermittent bioenergetic challenges, most notably exercise and dietary energy restriction, can increase the likelihood that the brain will function optimally and in the absence of disease throughout life. Expand
Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.
TLDR
Evidence of oxidative stress in aging brain, some of the most important neurodegenerative diseases, and in two common and highly disabling vascular pathologies--stroke and cardiac failure are reviewed. Expand
Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats
TLDR
The studies demonstrate a causal relationship between vitamin D status and cognitive function and suggest that vitamin D-mediated changes in hippocampal gene expression may improve the likelihood of successful brain aging. Expand
Brain Mitochondrial Dysfunction in Aging, Neurodegeneration, and Parkinson's Disease
TLDR
High doses of vitamin E produce a significant protection of complex I activity and mitochondrial function in rats and mice, and with improvement of neurological functions and increased median life span in mice. Expand
Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice.
TLDR
Observations suggest that a vitamin D3-enriched diet may benefit AD patients by decreasing the number of amyloid plaques, a decreases in Aβ peptides, a decrease in inflammation, and an increase in NGF in the brains of AβPP mice. Expand
Nutraceutical intervention in ageing brain
TLDR
Improved consumption of specific nutrients such as polyphenols, fish and seafood, vitamins and oligoelements has demonstrated protective effects by targeting specific cellular markers and cellular functions, and insights into the cellular mechanisms underlying this process are described. Expand
...
1
2
3
4
5
...