Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.

@article{Surez2002BiochemicalDI,
  title={Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.},
  author={Tatiana Su{\'a}rez and Subhasis B. Biswas and Esther E. Biswas},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 24},
  pages={21759-67}
}
The retina-specific human ABC transporter (ABCR) functions in the retinal transport system and has been implicated in several inherited visual diseases, including Stargardt disease, fundus flavimaculatus, cone-rod dystrophy, and age-related macular degeneration. We have previously described a general ribonucleotidase activity of the first nucleotide binding domain (NBD1) of human ABCR (Biswas, E. E. (2001) Biochemistry 40, 8181-8187). In this communication, we present a quantitative study… CONTINUE READING
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