Biochemical control of CARM1 enzymatic activity by phosphorylation.

  title={Biochemical control of CARM1 enzymatic activity by phosphorylation.},
  author={Qin Fu Feng and Bin He and Sung-Yun Jung and Yongcheng Song and Jun Qin and Sophia Y. Tsai and Ming-jer Tsai and Bert W O'malley},
  journal={The Journal of biological chemistry},
  volume={284 52},
Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein. However, the regulation of CARM1 enzymatic activity and substrate specificity remains largely unknown. In this… CONTINUE READING
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Regulation of CARM1 Enzymatic Activity by Phosphorylation 36174 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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