Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells.

@article{Jayaram1993BiochemicalCO,
  title={Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells.},
  author={Hiremagalur N. Jayaram and Weining Zhen and K Gharehbaghi},
  journal={Cancer research},
  year={1993},
  volume={53 10 Suppl},
  pages={2344-8}
}
Tiazofurin exhibits antitumor activity in murine and human tumor cells. In a recent phase I/II trial in patients with end-stage leukemia, tiazofurin showed good response; however, repeated treatment resulted in clinical resistance to the drug. To elucidate the mechanisms of resistance in human leukemic cells, two variants of human myelogenous leukemia K652 cells resistant to tiazofurin were developed by drug-selection pressure. Compared to a concentration producing 50% cell proliferation… CONTINUE READING
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