Biochemical characterization of the recombinant human Nogo-A ectodomain.

  title={Biochemical characterization of the recombinant human Nogo-A ectodomain.},
  author={Hilke Zander and Eva Hettich and Kathrin Greiff and Lorenz Chatwell and Arne Skerra},
  journal={The FEBS journal},
  volume={274 10},
Nogo-A is a physiologically relevant inhibitor of neuronal growth and regeneration in the myelin of the adult human central nervous system and has attracted considerable attention as a molecular target for the treatment of spinal cord injuries. To gain insight into the structural and functional properties of the large extramembrane region that is characteristic for the Nogo-A splice form of this member of the Reticulon family of membrane proteins, we cloned and expressed the region comprising… CONTINUE READING


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