Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate.

@article{Latour2010BiochemicalCO,
  title={Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate.},
  author={Derek R Latour and Andreas Jekle and Hassan Javanbakht and Robert Henningsen and Peter Gee and Ina H Lee and Patricia Q Tran and Suping Ren and Alan K Kutach and Seth F. Harris and Sandra M. Wang and Stephen J Lok and David Shaw and Jim enez A Li and Gabrielle M Heilek and Klaus Klumpp and David C. Swinney and Jerome Deval},
  journal={Antiviral research},
  year={2010},
  volume={87 2},
  pages={213-22}
}
Dengue virus (DENV), an emerging pathogen from the Flaviviridae family with neither vaccine nor antiviral treatment available, causes a serious worldwide public health threat. In theory, there are several ways by which small molecules could inhibit the replication cycle of DENV. Here, we show that the nucleoside analogue beta-d-2'-ethynyl-7-deaza-adenosine inhibits representative strains of all four serotypes of DENV with an EC(50) around or below 1microM. Using membrane-associated native… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

An adenosine nucleoside inhibitor of dengue virus.

Proceedings of the National Academy of Sciences of the United States of America • 2009

Antiviral agents acting asDNAorRNAchain terminators

E. DeClercq, J. Neyts
Handb . Exp . Pharmacol . • 2009

Structure and functionality in flavivirus Ns - proteins : perspectives for drug design

M. ollati, K. Alvarez, +7 authors E. A. Gould
Antiviral Res . . • 2009

Similar Papers

Loading similar papers…