Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target.

Abstract

INTRODUCTION Dihydrofolate reductase (DHFR) has been used successfully as a drug target in the area of anti-bacterial, anti-cancer and anti-malarial therapy. Although this bifunctional enzyme is also a potential drug target for treatment of leishmaniasis, there have been no reports on its efficacy against Leishmania (Viannia) species. MATERIALS AND… (More)

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@article{Osorio2013BiochemicalCO, title={Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target.}, author={Edison Osorio and Carolina A Aguilera and Nelson Naranjo and Marcel Mar{\'i}n and Carlos Muskus}, journal={Biomedica : revista del Instituto Nacional de Salud}, year={2013}, volume={33 3}, pages={393-401} }