Biochemical characterization of chitotriosidase enzyme: comparison between normal individuals and patients with Gaucher and with Niemann-Pick diseases.

@article{Wajner2004BiochemicalCO,
  title={Biochemical characterization of chitotriosidase enzyme: comparison between normal individuals and patients with Gaucher and with Niemann-Pick diseases.},
  author={Alessandro Wajner and Kristiane Michelin and Maira Graef Burin and Ricardo Flores Pires and Maria Luiza Saraiva Pereira and Roberto Giugliani and Janice Carneiro Coelho},
  journal={Clinical biochemistry},
  year={2004},
  volume={37 10},
  pages={893-7}
}
OBJECTIVES The aim of the present study was to establish the range of chitotriosidase (CT) activity in normal individuals, patients with Gaucher disease (GD) and Niemann-Pick disease (NPD), types A or B. The kinetics of CT in these three groups was also investigated. DESIGN AND METHODS CT activity, as well as Km, Vmax, optimum pH, and thermal stability of the enzyme were determined in the plasma of control, GD, and NPD subjects. RESULTS CT activity in GD and NPD patients was, respectively… CONTINUE READING

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