Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.

@article{Kremer2001BiochemicalCO,
  title={Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.},
  author={Laurent Kremer and Kesavan Madhavan Nampoothiri and Sarah Lesjean and Lynn George Dover and Sarabeth M Graham and Joanna Betts and Patrick Joseph Brennan and David E. Minnikin and Camille Locht and Gurdyal S Besra},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 30},
  pages={27967-74}
}
Malonyl coenzyme A (CoA)-acyl carrier protein (ACP) transacylase (MCAT) is an essential enzyme in the biosynthesis of fatty acids in all bacteria, including Mycobacterium tuberculosis. MCAT catalyzes the transacylation of malonate from malonyl-CoA to activated holo-ACP, to generate malonyl-ACP, which is an elongation substrate in fatty acid biosynthesis. To clarify the roles of the mycobacterial acyl carrier protein (AcpM) and MCAT in fatty acid and mycolic acid biosynthesis, we have cloned… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Acyl-coenzyme A:(holo-acyl carrier protein) transacylase enzymes as templates for engineering

Applied Microbiology and Biotechnology • 2018
View 10 Excerpts
Highly Influenced

Novel targets for tuberculosis drug discovery.

Current opinion in pharmacology • 2006
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…