Biochemical characterization and subcellular localization of human copper transporter 1 ( hCTR 1 )

@inproceedings{KLOMPBiochemicalCA,
  title={Biochemical characterization and subcellular localization of human copper transporter 1 ( hCTR 1 )},
  author={Adriana E. M. KLOMP and T. IngeE. and Van Den and BERG and R. G. Berger and Leo W. J. Klomp}
}
The human copper transporter 1 gene (hCTR1) was previously identified by functional complementation in ctr1-deficient yeast. Overexpression of hCTR1 in wild-type yeast leads to increased sensitivity to copper toxicity, and mice with a homozygous disruption at the Ctr1 locus die early during embryogenesis. It is proposed that hCTR1 is responsible for high-affinity copper uptake into human cells, but the underlying molecular mechanisms are unknown. To begin to investigate the biochemical… CONTINUE READING