Biochemical characteristics of gamma-glutamyl transpeptidase in capillaries from entorhinohippocampal complex of quinolinate-lesioned rat brain.

@article{astn1997BiochemicalCO,
  title={Biochemical characteristics of gamma-glutamyl transpeptidase in capillaries from entorhinohippocampal complex of quinolinate-lesioned rat brain.},
  author={Franti{\vs}ek {\vS}ťastn{\'y} and Lenka Dvoř{\'a}kov{\'a} and V{\'a}clav Lis{\'y}},
  journal={Molecular and chemical neuropathology},
  year={1997},
  volume={32 1-3},
  pages={143-61}
}
Quinolinic acid (QUIN) is an endogenous excitotoxic agonist of the N-methyl-D-aspartate (NMDA) type of glutamate receptor, which causes slowly progressing degeneration of vulnerable neurons in some brain regions. Using changes in the activity of membrane-bound gamma-glutamyl transpeptidase (GGT) as a marker of cell damage, we found a significant decrease of this enzyme activity, which was preferentially located in the ipsilateral hippocampal formation and entorhinal cortex, 4 d after the… CONTINUE READING