Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies

@article{Kalyva2014BiochemicalCO,
  title={Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies},
  author={Athanasia Kalyva and Fragiskos I. Parthenakis and Maria E. Marketou and Joanna E. Kontaraki and Panos E Vardas},
  journal={Journal of Muscle Research and Cell Motility},
  year={2014},
  volume={35},
  pages={161-178}
}
Cardiac muscle contraction occurs through an interaction of the myosin head with the actin filaments, a process which is regulated by the troponin complex together with tropomyosin and is Ca2+ dependent. Mutations in genes encoding sarcomeric proteins are a common cause of familial hypertrophic and dilated cardiomyopathies. The scope of this review is to gather information from studies regarding the in vitro characterisation of six HCM and six DCM mutations on the cardiac TnC gene and to… 
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TLDR
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TLDR
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