Biochemical changes in articular cartilage after joint immobilization by casting or external fixation

@article{Behrens1989BiochemicalCI,
  title={Biochemical changes in articular cartilage after joint immobilization by casting or external fixation},
  author={Frank Behrens and E. L. Kraft and Theodore R. Oegema},
  journal={Journal of Orthopaedic Research},
  year={1989},
  volume={7}
}
Knees of mature dogs were immobilized for 6 weeks by long‐leg casts allowing 8°–15° of motion, a model studied by others, or with external fixators, a new, more severe model that kept the joints rigid. Some animals were allowed to recover for 1 week after the immobilization period. Articular cartilage was examined histologically and biochemically. After 6 weeks of immobilization, water increased 7% in both casted and fixator‐immobilized joints compared with normal knee cartilage, while… 
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