Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues

@article{Monfort2008BiochemicalBO,
  title={Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues},
  author={Jordi Monfort and J. P. Pelletier and Nat{\`a}lia Garcia-Giralt and Johanne Martel-Pelletier},
  journal={Annals of the Rheumatic Diseases},
  year={2008},
  volume={67},
  pages={735 - 740}
}
Osteoarthritis is a chronic disease characterised by irreversible damage to joint structures, including loss of articular cartilage, osteophyte formation, alterations in the subchondral bone and synovial inflammation. Pain, functional disability and impairment of health-related quality of life are major complaints in patients with osteoarthritis. Several compounds have been investigated for their positive effects on the relief of clinical symptoms and improvement of structural changes in… 
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108 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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108 Citations

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Citation Type

Chondroitin sulphate: a focus on osteoarthritis
TLDR
This review highlights the potential of CS, either alone or in combination with other drugs, to attract the scientists engaged in OA treatment and management across the world.
Effect of chondroitin sulfate on cartilage volume loss and subchondral bone marrow lesions in osteoarthritis knee
TLDR
CS treatment significantly reduces the cartilage volume loss and subchondral BMLs in primary knee OA after 6 months of treatment, which suggested a joint structure-protective effect of CS.
Access to Highly Purified Chondroitin Sulfate for Appropriate Treatment of Osteoarthritis: A Review
TLDR
Highly-purified pharmaceutical-grade chondroitin sulfate has mild-to-moderate efficacy in the treatment of symptomatic osteoarthritis, with clinically meaningful efficacy.
Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate
TLDR
It is vitally important that only pharmaceutical-grade chondroitin sulfate be used for treating osteoarthritis patients, because some showed anti-inflammatory effects, others demonstrated weak effects, and some instances were even pro-inflammatory.
Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment
TLDR
The data support that hpCS is an effective and safe treatment of OA, with its effect already evident at 30 days; in addition, its beneficial action is prolonged, being maintained for at least 3 months after the drug is discontinued.
Immunomodulatory and anti-inflammatory effects of chondroitin sulphate
TLDR
This data indicates that chondroitin sulphate may be helpful in the treatment of autoimmune diseases and in degenerative diseases of the central nervous system (CNS).
Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses
TLDR
Data provided by meta-analyses indicate that CS has a slight to moderate efficacy in the symptomatic treatment of OA, with an excellent safety profile.
Hyaluronic Acid Prevent Further Cartilage Damage of Osteoarthritis Based on Expression of Collagen Type II and Collagen Type X
TLDR
The administration of HA results in an increased number of COL2 and reduced number ofCOL10 and has the potential function of inhibiting the degeneration process in joint cartilage.
Effect of mesenchymal stem cells combined with chondroitin sulfate in an in vitro model of osteoarthritis.
TLDR
This study shows the effectiveness of combining ASCs and CS in the treatment of OA, and shows that both treatments reduced expression of all genes associated with the pro-inflammatory cytokines.
Nutraceuticals in Arthritis
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