Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism.

@article{Pardo1985BiochemicalBO,
  title={Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism.},
  author={Jos{\'e} Manuel Pardo and Francisco Malpartida and Manuel Rico and Antonio Jim{\'e}nez},
  journal={Journal of general microbiology},
  year={1985},
  volume={131 6},
  pages={1289-98}
}
Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Streptomyces hygroscopicus. Ribosomes from this Gram-positive mycelial bacterium are inhibited in vitro by the antibiotic. In contrast, the streptomycete is highly resistant to the drug in vivo since it possesses hygromycin B phosphotransferase activity. This enzyme has been shown by gel filtration to have a molecular weight of 42000, and to modify its antibiotic substrate to produce 7… CONTINUE READING

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Molecular cloning and expression in Streptomyces lividans of a hygromycin B phosphotransferase gene from Streptomyces hygroscopicus

J. JIMENEZ, J. DAVIES
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Translation of poly ( U ) on ribosomes from Streptomyces aureo - faciens

K. MIKULIK, A. JIRANOVA, +3 authors N. QUYEN
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