Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.

@article{Hinnen1998BiochemicalBO,
  title={Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.},
  author={Petra Hinnen and Felix W. M. de Rooij and Marie-Louise F. van Velthuysen and Annie Edixhoven and Richard van Hillegersberg and Hugo W G Tilanus and John P. Wilson and Peter D. Siersema},
  journal={British Journal of Cancer},
  year={1998},
  volume={78},
  pages={679 - 682}
}
Administration of 5-aminolaevulinic acid (ALA) leads to porphyrin accumulation in malignant and premalignant tissues, and ALA is used as a prodrug in photodynamic therapy (PDT). To understand the mechanism of porphyrin accumulation after the administration of ALA and to investigate whether ALA-induced protoporphyrin IX might be a suitable photosensitizer in Barrett's oesophagus and adenocarcinoma, we determined the activities of porphobilinogen deaminase (PBG-D) and ferrochelatase (FC) in… CONTINUE READING