Biochemical basis for the resistance of guinea-pig and monkey to the carcinogenic effects of arylamines and arylamides.

@article{Razzouk1980BiochemicalBF,
  title={Biochemical basis for the resistance of guinea-pig and monkey to the carcinogenic effects of arylamines and arylamides.},
  author={C Razzouk and Manuel Mercier and Marcel B. Roberfroid},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1980},
  volume={10 7-8},
  pages={565-71}
}
1. Ag.l.c. assay for N-hydroxy-2-acetamidofluorene has been modified to measure both N-hydroxy-2-acetamidofluorene and N-hydroxy-2-aminofluorene. 2. Like guinea-pig, monkey N-hydroxylates both 2-aminofluorene and 2-acetamido-fluorene. The N-hydroxy metabolites are rapidly further metabolized even in the presence of inhibitors of deacetylase. The exact nature of this further metabolism is still unknown. Preliminary evidence indicates that, at least in the guinea-pig, 7-hydroxy-2… CONTINUE READING