Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation.

@article{Sheth2008BiochemicalBF,
  title={Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation.},
  author={Payal R. Sheth and John L Hays and Lisa A. Elferink and Stanley J. Watowich},
  journal={Biochemistry},
  year={2008},
  volume={47 13},
  pages={4028-38}
}
Ligand-induced dimerization of receptor tyrosine kinases (RTKs) modulates a system of linked biochemical reactions, sharply switching the RTK from a quiescent state to an active state that becomes phosphorylated and triggers intracellular signaling pathways. To improve our understanding of this molecular switch, we developed a quantitative model for hepatocyte growth factor receptor (c-MET) activation using parameters derived in large part from c-MET kinetic and thermodynamic experiments. Our… CONTINUE READING